You can find the current base Slic3r configurations on our download server. You can use the configurations to get started when you change your hardware- such as using a different sized nozzle.
Slic3r Configs
AO-100
[]0.5mm nozzle - point5mm.ini
[]0.35mm nozzle - point35mm.ini
[*]0.25mm nozzle - point25mm.ini
AO-101
[]3mm filament, 0.5mm nozzle, 0.3mm layer height - 3mm_pt5-nzl_pt3-lyr.ini
[]3mm filament, 0.5mm nozzle, 0.4 layer height - 3mm_pt5-nzl_pt4-lyr.ini
[]3mm filament, 0.35mm nozzle, 0.25 layer height - 3mm_pt35-nzl_pt25-lyr.ini
[]3mm filament, 0.25mm nozzle, 0.1mm layer height - 3mm_pt25-nzl_pt1-lyr.ini
Use the File>Import Config menu to import these Slic3r configs. Review and adjust your settings as necessary.