I’ve been using a fair bit of HIPS, mostly on Cura, but I’m working on getting Simplify3D dialed in.
When you say it doesn’t adhere, what are you talking about? The bed? Between each layer? Does the auto-leveling probe work properly?
I can get a decent print with the extruder temp set to 245, bed to 110, fan at 100% from the second layer. It’s not as nice as I would like right now, I get a better surface finish with Cura, in spite of so many reports saying how great Simplify3D is. It might be, once set up properly, but out of the box, I find Cura works well. Interestingly, I got better results with Nylon in S3D than in Cura… 
If you aren’t getting good bed adhesion, try adjusting the Z offset in the G-Code tab. You might want to try a -0.02 to get closer to the bed. With HIPS, I needed to get away a bit, it was sticking too well. Increasing first layer height/width might help as well. As usual, try one thing at a time and test with a small print.
Before starting, try opening the jog controls and heat the extruder. Once it’s at temp, extrude 10mm at a time manually till you get a good even extrusion. It seems to help the beginning of the print to prime the nozzle this way. I also increase the skirt for the same reason, adding width.