Try bringing your nozzle close to extrusion temp and clean it with a scotchbrite non-scratching scrub pad. Remove everything. I just pinch the nozzle with the scotchbrite and twist.
Then make sure your wipe pad is clean so the nozzle won’t pick up any debris while cleaning itself. I pick out little plastic pieces with tweezers and an exacto knife after each print. Try not to rip the pad up when prying away stuff as you don’t want the hard pad to become a fuzz ball.
Also when changing filaments, be sure to extrude/purge the old stuff out completely. There could be little pieces of burnt leftovers in the nozzle, so really try to clear everything out and extrude like 8" of the new filament until it’s pure. I think this is especially important when changing the type of filament you are using and not just the color.