What size nozzle are you using? If you’re using the recommended brands of filament you shouldn’t have clogging. You may have heat creep instead. Do you use active cooling on your hot end cooling fins?
To answer your question, using PTFE on the nozzle threads isn’t recommended if you plan on changing nozzles frequently. Instead, use a high-temperature threadlock: https://www.lulzbot.com/content/budaschnozzle-20-pla-solution