We do a lot of testing of specific manufacturer filaments with our printers, as one manufacturers PLA is not the same formula as another manufacturers PLA. We usually go through 7-10kgs testing and verifying settings for our printers before including them within Cura LE. A temperature tower (Where you change the extrusion temperature every 5mm or so) is a great place to start, as that is usually the easiest to nail down.
We have had some great user posts about testing and modifying for a great profile as well: A Strategy for Obtaining Great Prints
Good luck and happy printing!